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Stat Med. 1995 Dec 30;14(24):2661-74.

A personal view of some controversies in allocating treatment to patients in clinical trials.

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1
Medicine and Clinical Development Department, CIBA-GEIGY, Basle, Switzerland.

Abstract

A non-exhaustive but nevertheless wide-ranging if biased and personal view of various matters affecting the allocation of treatments to patients in controlled clinical trials will be undertaken from the standpoint of a statistician working in drug development. The following topics are considered: the use of ┬┐placebos' in the run-in phase; the use of crossover trials; selection of patients; various matters concerning centres; two extreme alternatives to randomization, and various matters linking blinding and allocation.

PMID:
8619106
[Indexed for MEDLINE]
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