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Eur J Immunol. 1996 Feb;26(2):365-9.

Human natural killer cell inhibitory receptors bind to HLA class I molecules.

Author information

1
Basel Institute for Immunology, Switzerland.

Abstract

To obtain direct evidence that human natural killer cell (NK) inhibitory receptors physically interact with polymorphic determinants of major histocompatibility complex class I molecules, a receptor termed NK-associated transcript-2 has been produced as a soluble fusion protein with the human IgG1 Fc portion. This soluble receptor binds specifically to HLA-C alleles with serine 77 and asparagine 80 in cell adhesion assays.

PMID:
8617305
DOI:
10.1002/eji.1830260215
[Indexed for MEDLINE]

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