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Br J Obstet Gynaecol. 1996 Feb;103(2):130-2.

Selenium deficiency and miscarriage: a possible link?

Author information

1
Department of Obstetrics and Gynaecology, Llandough Hospital, Penarth, United Kingdom.

Abstract

OBJECTIVE:

To investigate a possible relationship between a deficiency in serum selenium concentration and first trimester miscarriage.

DESIGN:

An observational study.

SETTING:

A teaching hospital in South Wales.

PARTICIPANTS AND METHODS:

Serum selenium, albumin and total protein concentration were measured in 40 women admitted with first trimester nonrecurrent miscarriage. The results were compared with an equal number of age-matched nonpregnant healthy volunteers, and also from 40 pregnant women attending the antenatal clinic for booking in the first trimester.

RESULTS:

A reduction in serum selenium normally occurs in the first trimester of pregnancies that progress to term. However, a further statistically highly significant decrease in serum selenium was observed in those women who miscarried.

CONCLUSION:

Further studies are required to assess the potential benefits of selenium supplements.

[Indexed for MEDLINE]

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