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Br J Haematol. 1996 Mar;92(4):947-9.

Human herpesvirus-6-associated exanthema in a patient with acute lymphocytic leukaemia.

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Department of Haematology / Chemotherapy, Clinical Research Institute, Kanagawa Cancer Centre, Yokohama, Japan.


We report the first case of human herpesvirus-6 (HHV-6) associated exanthema in a patient with acute lymphocytic leukaemia (ALL). We analysed DNA extracted from an exanthematous lesion using the polymerase chain reaction (PCR). DNA was positive for HHV-6 but negative for herpes simplex virus, varicella zoster virus, and cytomegalovirus. Immunohistochemical staining of the skin with monoclonal antibody against (HHV-6 confirmed the infection. The possibility of HHV-6 infection should be considered when an atypical skin rash is seen in patients with ALL.

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