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EMBO J. 1996 Apr 1;15(7):1632-41.

The pheromone response factor coordinates filamentous growth and pathogenicity in Ustilago maydis.

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1
Institut für Genetik und Mikrobiologie, Universität München, Germany.

Abstract

In Ustilago maydis, the a and b mating type loci regulate cell fusion, filamentous growth and pathogenicity. The a locus encodes a pheromone-based cell recognition system, and the b locus specifies two homeodomain proteins. The expression of all genes in the a and b loci is induced by pheromone. We have identified a HMG protein (Prf1) that binds sequence specifically to pheromone response elements present in the a and b loci. prf1 mutants do not express the a and b genes and are sterile. The disruption of prf1 in pathogenic haploid strains results in a loss of pathogenicity. The constitutive expression of the b genes restores pathogenicity and induces filamentous growth in the absence of the pheromone signal. These results provide evidence that pheromone signalling, filamentous growth and pathogenic development are linked through Prf1.

PMID:
8612587
PMCID:
PMC450074
[Indexed for MEDLINE]
Free PMC Article
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