Synthesis and characterization of iodixanol

Acta Radiol Suppl. 1995:399:21-31. doi: 10.1177/0284185195036s39903.

Abstract

Iodixanol (Visipaque) is a new nonionic roentgen contrast medium intended for general use. Visipaque is a pharmaceutical formulation of iodixanol which is isotonic and iso-osmotic with blood. Two synthetic routes from 5-nitro-isophthalic acid to iodixanol are described. The chemical structure is confirmed spectroscopical data ((1)H-NMR, (13)C-NMR, FAB-MS, UV, IR and Raman). Chromotographic characteristics are related to the isomerism of iodixanol.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Contrast Media / chemical synthesis*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Triiodobenzoic Acids / analysis
  • Triiodobenzoic Acids / chemical synthesis*
  • Triiodobenzoic Acids / chemistry

Substances

  • Contrast Media
  • Triiodobenzoic Acids
  • iodixanol