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Gastroenterology. 1996 Mar;110(3):682-7.

Better survival rates in patients with MLH1-associated hereditary colorectal cancer.

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1
Finnish Cancer Registry, Helsinki, Finland.

Abstract

BACKGROUND & AIMS:

Patients with hereditary nonpolyposis colorectal can cer (HNPCC) have been suggested to have a better prognosis than patients with common sporadic colorectal cancer. However, the evidence has not been convincing. The aim of this population-based study was to compare the survival rates of 175 patients with HNPCC with those of 14,000 patients with sporadic colorectal cancer diagnosed at <65 years of age in Finland from 1953 to 1993.

METHODS:

The recent progress in molecular genetics of hereditary colorectal cancer was utilized for the first time. One hundred twenty of the patients with HNPCC came from families segregating a germline mutation in the MLH1 cancer predisposition gene.

RESULTS:

The overall 5-year cumulative relative survival rate was 65% for patients with HNPCC and 44% for patients with sporadic colorectal cancer. The relative survival rates of patients with HNPCC were better in every strata analyzed.

CONCLUSIONS:

MLH1-associated colorectal cancer has a natural history different from that of common sporadic colorectal cancer. The better survival rates may be caused by the heavy mutation burden affecting mismatch repair deficient tumor cells.

PMID:
8608876
[Indexed for MEDLINE]
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