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Curr Opin Cell Biol. 1995 Dec;7(6):790-7.

Starting the cell cycle: what's the point?

Author information

1
Rockefeller University, New York, USA. fcross@rockvax.rockefeller.edu

Abstract

Early work on regulation of the budding yeast cell cycle defined a critical regulatory step called 'Start', considered to represent cell cycle commitment. Recent work has defined the probable molecular basis of Start to be activation of Cln-Cdc28 protein kinase complexes. Cln-Cdc28 kinases may directly regulate many cell cycle processes, including some classically considered to be 'post-Start'. Specialization of function among the three genetically redundant CLN genes is becoming apparent.

PMID:
8608009
DOI:
10.1016/0955-0674(95)80062-x
[Indexed for MEDLINE]

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