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Urology. 1996 Feb;47(2):225-31.

Local recurrence after radical prostatectomy: characteristics in size, location, and relationship to prostate-specific antigen and surgical margins.

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1
Department of Urology, University of California School of Medicine, San Francisco, CA 94143-0738, USA.

Abstract

OBJECTIVES:

To define the sonographic characteristics of local cancer recurrence after radical prostatectomy.

METHODS:

in 114 patients with an elevated prostate-specific antigen (PSA) and negative bone scan, 156 ultrasound-guided prostate fossa biopsies were carried out.

RESULTS:

in 53.5%, biopsy proved local recurrence. More than one ultrasound-guided biopsy session was required to make the diagnosis in 33% of patients. Local recurrence was seen on ultrasound at the anastomotic site (66%), the bladder neck (16%), and posterior to the trigone (13%). in 5% of patients there was a normal-appearing anastomotic site. Transrectal ultrasound was greater than 90% sensitive in detecting local recurrence, but lacked specificity. Examination of the radical prostatectomy specimens in patients with local recurrence showed positive surgical margins in 66% and organ-confined disease in 20%.

CONCLUSIONS:

Transrectal ultrasonography is a useful adjunct to PSA and digital rectal examination in the detection of local recurrences following radical prostatectomy.

PMID:
8607239
DOI:
10.1016/S0090-4295(99)80421-X
[Indexed for MEDLINE]
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