Format

Send to

Choose Destination
See comment in PubMed Commons below
Reprod Fertil Dev. 1995;7(3):517-20.

Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS.

Author information

1
Department of Obstetrics and Gynaecology, Pediatrics and Physiology, University of Alberta, Edmonton, Canada.

Abstract

The human amnion is an excellent model in which to study the regulation of the expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) mRNA by glucocorticoids, as glucocorticoids can both stimulate and inhibit PGHS activity and can have their stimulatory effect reversed to an inhibitory one. Our studies suggest the presence of a glucocorticoid-induced inhibitory protein which affects the post-transcriptional activity of PGHS-2 mRNA. Glucocorticoid-induced expression of PGHS-2 mRNA may be dependent on protein phosphorylation.

PMID:
8606963
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center