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Nature. 1996 Apr 11;380(6574):495-8.

Essential flexibility in the T-cell recognition of antigen.

Author information

1
Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Abstract

alpha beta T cells specifically recognize a ligand composed of a peptide bound to a self-major-histocompatibility-complex molecule, but the recognition of slightly altered ligands by T cells can lead to a partial activation. This flexibility is crucial for T-cell development and can have both beneficial and harmful effects on peripheral T cells.

PMID:
8606766
DOI:
10.1038/380495a0
[Indexed for MEDLINE]

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