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Biochim Biophys Acta. 1996 Feb 7;1305(1-2):34-8.

Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter.

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Department of Clinical Nutrition, School of Medicine, Tokushima University, Japan.


Complementary DNA clones encoding the rat PepT1 small-intestinal oligopeptide transporter were isolated from a jejunal library by cross-hybridization with a rabbit PepT1 cDNA probe. The cDNA sequence indicates that rat PepT1 is composed of 710 amino acids and shows 77% and 83% amino acid sequence identity with rabbit and human PepT1, respectively. Northern blot analysis detected rat PepT1 mRNA in the small intestine and kidney. Intestinal PepT1 mRNA levels were highest in 4-day old rats, and then decreased reaching the adult level by day 28 after birth. These results indicate that the expressions of PepT1 gene change markedly during development.

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