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Cancer Lett. 1996 Apr 19;102(1-2):7-16.

MDR1 and multidrug resistance-associated protein (MRP) gene expression in epithelial ovarian tumors.

Author information

1
Children's Leukaemia and Cancer Research Centre, Prince of Wales Children's Hospital, Sydney, New South Wales, Australia.

Abstract

Clinical drug resistance poses a major problem in the successful treatment of ovarian cancer. Two genes, MDR1 and MRP, have been found to play a role in the multidrug resistance phenotype of a number of human tumors. Using a sensitive semiquantitative PCR assay we examined 53 primary untreated ovarian tumors for expression of both MDR1 and MRP genes. Approximately one-third of the tumors expressed MDR1 while all the tumors expressed varying levels of the MRP gene.

PMID:
8603381
DOI:
10.1016/0304-3835(96)04143-2
[Indexed for MEDLINE]

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