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Nature. 1996 Apr 4;380(6573):403-9.

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase.

Author information

1
Unité de Neurobiologie et Pharmacologie de l'INSERM, Centre Paul Broca, Paris, France.

Abstract

A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. Butabindide, a potent and specific inhibitor, was designed and shown to protect endogenous cholecystokinin from inactivation and to display pro-satiating effects mediated by the CCKA receptor.

PMID:
8602240
DOI:
10.1038/380403a0
[Indexed for MEDLINE]

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