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Mamm Genome. 1995 Nov;6(11):763-8.

A high-resolution genetic map of mouse chromosome 15 encompassing the Dominant megacolon (Dom) locus.

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  • 1Unité INSERM U91. Hôpital Henri Mondor, Créil, France.


Dominant megacolon (Dom) is one of four mutations in the mouse that can produce a phenotype similar to Hirschsprung disease in human. The Dom gene product is not known, and no candidate region has been defined for a possible human homolog. In this publication we report mapping the Dom locus with high definition, using several intra-and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus.

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