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FEMS Microbiol Lett. 1996 Jan 15;135(2-3):237-43.

A stable Escherichia coli-mycobacteria shuttle vector 'pSO246' in Mycobacterium bovis BCG.

Author information

1
Nagasaki University, School of Dentistry, Japan.

Abstract

The most widely used plasmid vector system in mycobacteria is based on pAL5000 from Mycobacterium fortuitum. The derivatives of the pAL5000-based shuttle vectors between Escherichia coli and mycobacteria, which we have utilized to secrete recombinant antigens, were generated. The stability of the vectors was assessed in Mycobacterium bovis BCG (BCG). The plasmid vector pSO246 was stable in BCG for at least 50 generations.

PMID:
8595863
DOI:
10.1016/0378-1097(95)00457-2
[Indexed for MEDLINE]

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