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Neuroreport. 1995 Nov 13;6(16):2193-6.

Expression of melanocortin 1 receptor in periaqueductal gray matter.

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1
Department of Pharmaceutical Biosciences, Uppsala University, Sweden.

Abstract

The localization of the melanocortin 1 (MC1) receptor in brain was investigated by in situ hybridization and immunohistochemistry. In rat periaqueductal gray matter (PAG), a small number of cells which displayed a punctate distribution showed a specific hybridization signal for MC1 receptor mRNA, whereas other regions studied were negative. In human PAG, the immunoreactivity for MC1 receptor was detected in scattered cells. These results indicate that a restricted distribution of MC1 receptor is present in the central nervous system.

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