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J Neurotrauma. 1995 Oct;12(5):903-6.

The neurochemical and metabolic cascade following brain injury: moving from animal models to man.

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Department of Surgery, UCLA School of Medicine 90024, USA.


Experimental traumatic brain injury produces a series of cellular events contributing to a neurochemical and neurometabolic cascade. This cascade is defined by the release of neurotransmitters resulting in a massive ionic flux, which, consequently, produces an increase in glycolysis. This increase in glycolysis is followed by a metabolic diaschisis, which is related to the degree and extent of behavioral deficits. Clinical efforts have now determined that a similar cascade occurs in human head injury, validating the animal model as well as providing new assessment strategies for the management and treatment of brain injury.

[Indexed for MEDLINE]

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