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J Antimicrob Chemother. 1995 Oct;36(4):723-8.

Sulfadoxine/pyrimethamine or chloroquine/clindamycin treatment of Gabonese school children infected with chloroquine resistant malaria.

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1
International Research Laboratory, Albert-Schweitzer-Hospital, Lambaréné, Gabon, Austria.

Abstract

In a randomized trial, a high dosage chloroquine monotherapy (45 mg/kg over 3 days) was compared with combination regimens of sulfadoxine/pyrimethamine and chloroquine/clindamycin for treating Gabonese school children with Plasmodium falciparum malaria. In chloroquine treated patients only 32% were ultimately cured. In contrast, more than 90% of patients were cured after treatment with either combination regimen.

PMID:
8591949
[Indexed for MEDLINE]
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