Format

Send to

Choose Destination
J Ocul Pharmacol Ther. 1995 Fall;11(3):213-20.

Vaninolol: a novel compound for the treatment of glaucoma and ischemic retinopathy.

Author information

1
Department of Pharmacology, Kaohsiung Medical College, Taiwan, Republic of China.

Abstract

Vaninolol has been confirmed as a selective beta 1-adrenergic blocking agent. The new compound was studied for its effects on intraocular pressure (IOP), the ocular blood flow and the retinal function in this report. Vaninolol showed marked delay in IOP recovery demonstrating that the agent possessed an ocular hypotensive action. This effect is equipotent or slightly more active than L-timolol. In addition, effects of vaninolol on the ocular blood flow of ocular hypertensive eyes were determined using the colored microspheres technique. It was found that vaninolol improved the ocular blood flow in ciliary body and retina, but not in iris and choroid. Further, vaninolol is able to improve the b-wave recovery in electroretinography significantly, indicating that it is possible to develop a new agent for the treatment of ischemic retinopathy.

PMID:
8590252
DOI:
10.1089/jop.1995.11.213
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center