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Arch Microbiol. 1995 Dec;164(6):383-9.

Molecular mechanisms of endotoxin activity.

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1
Forschungsinstitut Borstel, Institut für Experimentelle Biologie und Medizin, Parkallee 22, D-23845 Borstel, Germany.

Abstract

Endotoxin (lipopolysaccharide, LPS), a constituent of the outer membrane of the cell wall of gram-negative bacteria, exerts a wide variety of biological effects in humans. This review focuses on the molecular mechanisms underlying these activities and discusses structure-function relationships of the endotoxin molecule, its interaction with humoral and cellular receptors involved in cell activation, and transmembrane and intracellular signal transduction pathways.

PMID:
8588739
[Indexed for MEDLINE]
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