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Psychol Med. 1995 Sep;25(5):995-1001.

Biochemical and behavioural effects of acute tryptophan depletion in abstinent bulimic subjects: a pilot study.

Author information

1
Department of Psychiatry, University of Oxford.

Abstract

We studied the effect of acute tryptophan (TRP) depletion in a group of eight abstinent bulimic (BN) subjects and in 12 healthy female controls. Despite being free of episodes of binge-eating and vomiting for a prolonged period, the abstinent BN subjects still appeared to practice dietary restrain as judged by their food intake in a test meal. In addition, their plasma TRP concentrations were significantly lower than those of the controls. Administration of a TRP-free amino acid load (52 g) significantly lowered plasma total and free TRP. However, compared to a balanced amino acid load, this procedure did not have significant effects on mood, appetite or food intake in either the abstinent BN subjects or the healthy controls.

PMID:
8588018
[Indexed for MEDLINE]

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