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J Urol. 1996 Mar;155(3):952-4.

Delayed orchiectomy after chemotherapy for metastatic nonseminomatous germ cell tumors.

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1
Department of Urology, Indiana University Medical Center, Indianapolis, USA.

Abstract

PURPOSE:

We reviewed current experience at our university with delayed orchiectomy after chemotherapy in patients with metastatic nonseminomatous germ cell tumors.

MATERIALS AND METHODS:

We retrospectively analyzed the records of 160 patients with metastatic germ cell cancer who were given systemic chemotherapy, and subsequently underwent orchiectomy and retroperitoneal lymph node dissection.

RESULTS:

Analysis of 160 testicular specimens revealed necrosis or scar in 70 (43.7%), pure teratoma in 50 (31.2%) and persistent germ cell cancer in 40 (25%). Corresponding incidences of histopathological findings in the post-chemotherapy retroperitoneal lymph node dissection specimens were significantly different, correlating with less than half of the cases (chi-square, p = 0.002).

CONCLUSIONS:

Our study confirms the need for delayed orchiectomy after systemic chemotherapy even when there seems to be a partial or complete clinical response at other sites.

PMID:
8583615
[Indexed for MEDLINE]
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