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Protein Sci. 1995 Dec;4(12):2621-4.

Ethanol utilization regulatory protein: profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion.

Author information

1
Pittsburgh Supercomputing Center, Pennsylvania 15213, USA. nicholas@psc.edu

Abstract

The suggestion that the ethanol regulatory protein from Aspergillus has its evolutionary origin in a gene fusion between aldehyde and alcohol dehydrogenase genes (Hawkins AR, Lamb HK, Radford A, Moore JD, 1994, Gene 146:145-158) has been tested by profile analysis with aldehyde and alcohol dehydrogenase family profiles. We show that the degree and kind of similarity observed between these profiles and the ethanol regulatory protein sequence is that expected from random sequences of the same composition. This level of similarity fails to support the suggested gene fusion.

PMID:
8580855
PMCID:
PMC2143040
DOI:
10.1002/pro.5560041221
[Indexed for MEDLINE]
Free PMC Article

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