Format

Send to

Choose Destination
Curr Opin Neurobiol. 1995 Oct;5(5):647-55.

HIV interactions with cells of the nervous system.

Author information

1
D├ępartement de Virologie, Institut Pasteur, Paris, France. mdalcq@pasteur.fr

Abstract

HIV can invade the CNS, where it replicates principally in macrophages. Yet, neurological disease is more often correlated with levels of neurotoxins or tumor necrosis factor alpha than with viral replication or specific viral determinants in brain. In experimental systems, HIV glycoprotein affects functions of uninfected microglia and astrocytes to eventually cause neuronal death. While the cellular basis of cognitive and neurological dysfunction are unravelled in the simian immunodeficiency virus model, the molecular mechanisms of HIV neurotoxicity are being studied in newly developed mouse models.

PMID:
8580717
DOI:
10.1016/0959-4388(95)80071-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center