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Curr Opin Neurobiol. 1995 Oct;5(5):559-65.

The function of dynamin in endocytosis.

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Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.


Temperature-sensitive shibire mutants of Drosophila melanogaster become rapidly paralyzed upon a shift to the restrictive temperature, which is due to a block in synaptic vesicle endocytosis. The shibire gene encodes the GTPase dynamin. Recent studies have shown that dynamin forms rings at the neck of invaginated clathrin-coated pits, and have suggested that a conformational change in the ring, which correlates with GTP hydrolysis, plays an essential role in vesicle fission.

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