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Chin Med Sci J. 1995 Sep;10(3):185-7.

Treatment of 23 patients with advanced gastric cancer by intravenously transfer of autologous tumor-infiltrating lymphocytes combined with rIL-2.

Author information

1
Military Medical Institute, Nanjing Military Area.

Abstract

Tumor-infiltrating lymphocytes (TIL) isolated from metastatic lymph nodes in patients with nonoperable advanced gastric cancer were induced to become LAK-like cytotoxic activity of TIL after in vitro culture with rIL-2. Twenty-three patients with advanced gastric cancer were treated by intravenously transfer of autologous TIL combined with rIL-2. The tumor focus disappeared (complete remission, CR) in 3 patients (13.0%) and significantly decreased (partial remission, PR) in 5 patients (21.7%). Fifteen patients did not respond to the treatment. The amount of soluable IL-2 receptor in serum was significantly decreased after treatment, the cytotoxicity of NK cells and OT test were significantly increased. No significant difference in CD4/CD8 was found between before and after treatment. No serious side effect was observed in the treatment.

PMID:
8580492
[Indexed for MEDLINE]

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