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Bone. 1995 Nov;17(5):437-45.

The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development.

Author information

1
Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA.

Abstract

Experimental studies of the mammalian osteopetroses, characterized by generalized skeletal sclerosis, have illuminated a variety of mechanisms by which bone resorption can be reduced. We review recent data implicating a diverse group of growth factors, proto-oncogenes, and immune regulators that can influence skeletal development and account for the heterogeneity of the osteopetroses. Furthermore, similar studies are likely to continue to provide for improved clinical management of both osteopetrotic children and the localized and generalized osteopenias.

PMID:
8579954
DOI:
10.1016/8756-3282(95)00347-4
[Indexed for MEDLINE]

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