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Immunol Today. 1995 Dec;16(12):588-95.

Analysis of TCR usage in human tumors: a new tool for assessing tumor-specific immune responses.

Author information

1
Division of Experimental Oncology D, Istituto Nazionale Tumori, Milan, Italy.

Abstract

Tumor-infiltrating lymphocytes (TILs), through displaying a T-cell receptor (TCR) repertoire as heterogeneous as that of normal peripheral blood T cells, show overexpression of TCR variable-gene segments that include clonally expanded TCR sequences. Here, Marialuisa Sensi and Giorgio Parmiani analyze the available information on TCR usage by T cells present in the infiltrate of histologically different tumors and suggest that the analysis of TCR sequences represents a powerful new tool to assess the in vivo immune response to growing tumors. Ultimately, this strategy may lead to the identification and manipulation of T-cell populations endowed with antitumor reactivity.

PMID:
8579752
DOI:
10.1016/0167-5699(95)80082-4
[Indexed for MEDLINE]

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