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South Med J. 1996 Feb;89(2):225-6.

Treatment of mania: relationship between response to verapamil and changes in plasma calcium and magnesium levels.

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Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Fla 33136, USA.


Twelve patients meeting DSM-IIIR criteria for mania received verapamil over a 2-week period, with dosing up to 360 mg/day. Severity of mania was measured at baseline and weekly by use of the Young Mania Scale. Plasma calcium and magnesium determinations and an ECG were obtained at baseline and after 2 weeks of treatment. Mean improvement was from a baseline of 32.4 to 12.8, -60.5%. Decreased severity of mania correlated significantly with increased plasma calcium. This result may lend a method for monitoring successful treatment of mania with calcium channel inhibitors.

[Indexed for MEDLINE]

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