Format

Send to

Choose Destination
Int Rev Cytol. 1995;162A:125-49.

The structural basis of nuclear function.

Author information

1
CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.

Abstract

Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.

PMID:
8575879
DOI:
10.1016/s0074-7696(08)61230-9
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center