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Genomics. 1995 Oct 10;29(3):571-5.

Parsimonious estimation of sex-specific map distances by stepwise maximum likelihood regression.

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Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, USA.


In human genetic maps, differences between female (xf) and male (xm) map distances may be characterized by the ratio, R = xf/xm, or the relative difference, Q = (xf - xm)/(xf + xm) = (R - 1)/(R + 1). For a map of genetic markers spread along a chromosome, Q(d) may be viewed as a graph of Q versus the midpoints, d, of the map intervals. To estimate male and female map distances for each interval, a novel method is proposed to evaluate the most parsimonious trend of Q(d) along the chromosome, where Q(d) is expressed as a polynomial in d. Stepwise maximum likelihood polynomial regression of Q is described. The procedure has been implemented in a FORTRAN program package, TREND, and is applied to data on chromosome 18.

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