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Clin Dysmorphol. 1995 Oct;4(4):359-63.

Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?

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  • 1Oxford Regional Genetics Service, Oxford Radcliffe Trust, UK.


Transverse limb defects are reported in a fetus and an infant born to mothers on treatment for hypertension. One pregnancy resulted in an intrauterine death at 20 weeks, and in addition to the limb defects, there was bilateral cleft lip and palate and renal hypoxic damage. It is proposed that the drugs caused maternal hypotension which led to reduced uteroplacental blood flow, fetal hypotension and hypoxia and that the anomalies seen in the two babies are a consequence of these events.

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