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Curr Opin Cell Biol. 1995 Oct;7(5):681-9.

Integrin transmembrane signaling and cytoskeletal control.

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Laboratory of Developmental Biology NIDR, NIH, Bethesda, MD 20892-4370, USA.


Integrins are remarkably multifunctional: they mediate cell adhesion and migration, orchestrate organization of the actin-based cytoskeleton, and activate signal transduction pathways. Recent studies have identified a variety of steps and hierarchies in these intracellular cytoskeletal and signaling responses, laying the groundwork for future studies on specificity and coordination with responses to growth factors.

[Indexed for MEDLINE]

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