Send to

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1995 Dec;20(12):511-6.

Finding prospective partners in the library: the two-hybrid system and phage display find a match.

Author information

  • 1Howard Hughes Medical Institute, Houston, TX, USA.


The two-hybrid system uses the efficacy of yeast genetic assays to identify protein-protein interactions. It permits the rapid cloning of genes encoding products that interact with a given protein of interest. Also being developed are phage display methods that allow direct physical selection of binding proteins. These methods have significantly altered strategies for analysing signaling and regulatory pathways.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center