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Psychiatry Res. 1995 Sep 29;58(2):171-6.

Decreased urinary peptide excretion in schizophrenic patients after neuroleptic treatment.

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Department of Pediatric Research, University of Oslo, Rikshospitalet, Norway.


Six schizophrenic patients had their urinary peptide levels measured before and after 5 weeks of treatment with neuroleptic medications. For two patients, levels were also measured after a reduction in the neuroleptic dose. Because of the heterogeneity of peptide peaks with the same bioactivity, the overall peptide levels were compared to initial levels. A neuroleptic effect on peptide levels was demonstrated. Several research groups have reported enzyme induction caused by neuroleptics in vivo.

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