Format

Send to

Choose Destination
See comment in PubMed Commons below
Psychiatry Res. 1995 Sep 29;58(2):161-4.

Induction of depersonalization by the serotonin agonist meta-chlorophenylpiperazine.

Author information

1
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.

Abstract

Sixty-seven subjects, including normal volunteers and patients with obsessive-compulsive disorder, social phobia, and borderline personality disorder, received ratings of depersonalization after double-blind, placebo-controlled challenges with the partial serotonin agonist meta-chlorophenylpiperazine (m-CPP). Challenge with m-CPP induced depersonalization significantly more than did placebo. Subjects who became depersonalized did not differ in age, sex, or diagnosis from those who did not experience depersonalization. There was a significant correlation between the induction of depersonalization and increase in panic, but not nervousness, anxiety, sadness, depression, or drowsiness. This report suggests that serotonergic dysregulation may in part underlie depersonalization.

PMID:
8570768
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center