Immunomodulatory action of propolis. VI. Influence of a water soluble derivative on complement activity in vivo

N D Ivanovska; V B Dimov; V S Bankova; S S Popov

doi:10.1016/0378-8741(95)01272-f

Immunomodulatory action of propolis. VI. Influence of a water soluble derivative on complement activity in vivo

J Ethnopharmacol. 1995 Jul 28;47(3):145-7. doi: 10.1016/0378-8741(95)01272-f.

Authors

N D Ivanovska¹, V B Dimov, V S Bankova, S S Popov

Affiliation

¹ Department of Immunology, Bulgarian Academy of Sciences, Sofia.

PMID: 8569238
DOI: 10.1016/0378-8741(95)01272-f

Abstract

The water soluble derivative (WSD) of propolis in a dose of 150 mg/kg was administered intravenously (i.v.), intraperitoneally (i.p.) and orally (p.o.) to mice. The alteration of serum alternative pathway (AP) complement level was observed. The WSD also influenced the process of acute inflammation provoked by zymosan in mice. The effect was strongly dependent on the route of WSD administration.

MeSH terms

Adjuvants, Immunologic / administration & dosage
Adjuvants, Immunologic / pharmacology*
Adjuvants, Immunologic / therapeutic use
Administration, Oral
Animals
Complement Hemolytic Activity Assay
Complement Pathway, Alternative / drug effects*
Edema / drug therapy
Female
Hindlimb
Inflammation / chemically induced
Inflammation / drug therapy
Injections, Intraperitoneal
Injections, Intravenous
Male
Mice
Mice, Inbred ICR
Propolis / administration & dosage
Propolis / pharmacology*
Propolis / therapeutic use
Solubility
Water / chemistry
Zymosan / administration & dosage
Zymosan / toxicity

Substances

Adjuvants, Immunologic
Water
Propolis
Zymosan