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J Infect Dis. 1996 Feb;173(2):484-7.

Route of infection determines the clinical manifestations of acute Q fever.

Author information

1
Department of Medicine, Dalhousie University, Halifax, Canada.

Abstract

In Nova Scotia the main manifestation of acute Q fever is pneumonia, while in France it is granulomatous hepatitis. To test the hypothesis that the route of infection is the major determinant of the manifestations of acute Q fever, 10 groups of 10- to 12-g female BALB/c mice (4 animals/group) were used. Five groups were inoculated intraperitoneally (ip) and 5 intranasally (inl) with Coxiella burnetii. Both routes of infection resulted in pneumonia. However, the inl route resulted in greater airway changes (on a numeric scale with 0 being no changes): 2.05 +/- 2.20 versus 0.60 +/- 0.83 (P < .002). The ip route resulted only in hepatosplenomegaly. It was concluded that the route of infection is one determinant of the manifestations of acute Q fever.

PMID:
8568318
DOI:
10.1093/infdis/173.2.484
[Indexed for MEDLINE]

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