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Gene. 1995 Dec 29;167(1-2):111-3.

Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter.

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Department of Biological Sciences, University of Maryland, Baltimore 21228, USA.


A region of the Staphylococcus aureus chromosome has been isolated that contains the gene encoding penicillin-binding protein 4 (PBP4), as well as abcA, a gene that encodes a protein with strong sequence similarity to the ABC transporter family of proteins. A disruption in abcA by Campbell-type integration results in cells that display an increased resistance to methicillin and cefoxitin, two antibiotics known to interact with low-molecular-weight PBPs. Based on these observations, a potential regulatory link between these two genes is discussed.

[Indexed for MEDLINE]

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