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Eur J Pharmacol. 1995 Oct 15;291(2):217-9.

Possible mechanism of oxygen radical production by human eosinophils mediated by K+ channel activation.

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Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, Chicago, IL 60611, USA.


Quinidine hydrochloride, as potent K+ channel blocker, reduced luminol-dependent chemiluminescence products evoked by the addition of the calcium ionophore A23187 to eosinophils from patients with hypereosinophilic syndrome (n = 3) in a concentration-dependent manner (10-5 mM quinidine). A23187 is known to cause increases in intracellular Ca2+ concentrations in eosinophils. Our results indicate that the production of reactive oxygen species by human eosinophils may be affected by Ca(+)-activated K+ channels.

[Indexed for MEDLINE]

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