Abstract
A series of fused pyrazole derivatives of cyclolignans have been prepared through simple chemical routes and evaluated for their cytotoxic activities in culture cells of P-388 murine leukemia, A-549 lung carcinoma and HT-29 colon carcinoma. Despite the lack of the lactone moiety in their structures, they show IC50 values at microM levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Drug Screening Assays, Antitumor
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HT29 Cells / drug effects
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Humans
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Leukemia P388 / drug therapy
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Lignans / chemical synthesis*
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Lignans / chemistry
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Lignans / pharmacology*
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Lung Neoplasms / drug therapy
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Magnetic Resonance Spectroscopy / methods
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Mice
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Lignans
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Pyrazoles