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Trends Microbiol. 1995 Oct;3(10):373-80.

The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments.

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Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, Facultad de Biología, Universidad Autónoma de Madrid, Spain.


Many bacterial pathogens and eukaryotic parasites can enter mammalian cells and live intracellularly inside membrane-bound vacuoles. The intravacuolar lifestyle of these pathogens plays a key role in pathogenesis. Understanding the molecular basis of the development of these specialized intracellular compartments is critical to understanding how these organisms cause disease.

[Indexed for MEDLINE]

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