Format

Send to

Choose Destination
Br J Cancer. 1996 Feb;73(3):366-71.

LOH at 3p correlates with a poor survival in oral squamous cell carcinoma.

Author information

1
Epithelial Cell Biology Unit, Department of Oral and Maxillofacial Surgery, King's College School of Medicine and Dentistry, London, UK.

Abstract

We analysed chromosome 3p for loss of heterozygosity (LOH) in 48 primary oral squamous cell carcinomas (SCCs) using 15 markers and constructed a deletion map for this chromosome arm. LOH at one or more loci was found in 34/48 (71%) of tumours. The data support the existence of at least three distinct regions of deletion at 3p24-26, 3p21.3-22.1 and 3p12.1-14.2. A significant correlation was observed between the number of regions showing allele loss at 3p and tumour stage, consistent with the progressive accumulation of genetic errors during the development of oral SCC. There were also significant associations between LOH at 3p and disease-free and overall survival of patients with early stage disease. This study is the first to demonstrate the prognostic significance of LOH at 3p for oral cancer and may help to identify patients who should receive more aggressive treatment.

PMID:
8562343
PMCID:
PMC2074435
DOI:
10.1038/bjc.1996.62
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center