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Acta Obstet Gynecol Scand. 1996 Jan;75(1):54-6.

Effect of vaginal misoprostol application for cervical softening in pregnancy interruption before ten weeks of gestation.

Author information

1
Zeynep Kamil Women's and Pediatric Hospital, Istanbul, Turkey.

Abstract

OBJECTIVE:

To determine the effect of vaginal misoprostol application for cervical dilatation and to determine the time taken for pregnancy interruption.

METHODS:

200 micrograms misoprostol and gyno-flor vaginal tablet, employed to create acidic milieu, were applied into the posterior fornix of 40 women with gestational age of 5 to 10 weeks. Placebo was applied vaginally to 20 women who made up the control group. All cases were examined 5 hours later. The cervical dilatation, presence of fetoplacental material in the vagina, extrauterine cervical bleeding and the time necessary for dilatation and suction curettage were investigated.

RESULTS:

In 33 (82.5%) of the cases cervical bleeding, in 21 (52.5%) of the cases fetoplacental material on the cervix and/or in the vagina were detected in women of misoprostol group, while neither cervical bleeding nor fetoplacental material on the cervix and/or in the vagina was detected in the placebo group. In the misoprostol group the time taken for the operation was significantly (p < 0.005) shorter than that of the control group.

CONCLUSION:

Vaginal application of misoprostol shortens the time needed for the termination of the gestation by its facilitating effect on cervical dilatation.

PMID:
8560998
[Indexed for MEDLINE]

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