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Neurology. 1996 Jan;46(1):254-6.

Late juvenile metachromatic leukodystrophy treated with bone marrow transplantation; a 4-year follow-up study.

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  • 1Department of Pathology and Neuropathology, Hospital do Meixoeiro, Vigo, Spain.


We treated a 28-year-old woman who had metachromatic leukodystrophy with bone marrow transplantation. Leukocyte arylsulfatase A levels increased to the donor's range after successful graft. Motor and sensory nerve conduction values did not change significantly in the 4 years after the transplant, and subcortical white matter lesions, as shown on MRI, remained stable during that period of time. The results, after 4 years of follow-up, indicate that the disease has not progressed and signs and symptoms are stabilized.

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