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Chem Res Toxicol. 1995 Oct-Nov;8(7):903-6.

Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan.

Author information

1
Division of Chemical Carcinogenesis, American Health Foundation, Valhalla, New York 10595, USA.

Abstract

The hepatocarcinogen furan is believed to be activated to the reactive aldehyde, cis-2-butene-1,4-dial, by microsomal enzymes. The rat liver microsomal metabolism of furan was examined in the presence of NADPH and semicarbazide. HPLC analysis of incubation mixtures revealed the formation of a metabolite that coeluted with standards for the bis-semicarbazone adduct of cis-2-butene-1,4-dial. The formation of this compound required the presence of NADPH, semicarbazide, and microsomes. Preparative isolation and chemical characterization of this metabolite confirmed the structural assignment. These data provide evidence that the reactive aldehyde, cis-2-butene-1,4-dial, is a major metabolic product of furan.

PMID:
8555403
DOI:
10.1021/tx00049a001
[Indexed for MEDLINE]

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