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Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):13-20.

Principles of protein-protein interactions.

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1
Department of Biochemistry and Molecular Biology, University College, London, England.

Abstract

This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.

PMID:
8552589
PMCID:
PMC40170
[Indexed for MEDLINE]
Free PMC Article
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