Format

Send to

Choose Destination
Nature. 1996 Jan 25;379(6563):343-6.

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.

Author information

1
Department of Neurology and Neurological Sciences, Stanford University Medical Center, California 94305, USA.

Erratum in

  • Nature 1998 Apr 9;392(6676):630.

Abstract

Following induction of experimental encephalomyelitis with a T-cell clone, L10C1, that is specific for the myelin basic protein epitope p87-99, the inflammatory infiltrate in the central nervous system contains a diverse collection of T cells with heterogeneous receptors. We show here that when clone L10C1 is tolerized in vivo with an analogue of p87-99, established paralysis is reversed, inflammatory infiltrates regress, and the heterogeneous T-cell infiltrate disappears from the brain, with only the T-cell clones that incited disease remaining in the original lesions. We found that antibody raised against interleukin-4 reversed the tolerance induced by the altered peptide ligand. Treatment with this altered peptide ligand selectively silences pathogenic T cells and actively signals for the efflux of other T cells recruited to the site of disease as a result of the production of interleukin-4 and the reduction of tumour-necrosis factor-alpha in the lesion.

PMID:
8552189
DOI:
10.1038/379343a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center