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Nature. 1996 Jan 25;379(6563):311-9.

The 2.0 A crystal structure of a heterotrimeric G protein.

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1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06510, USA.

Abstract

The structure of a heterotrimeric G protein reveals the mechanism of the nucleotide-dependent engagement of the alpha and beta gamma subunits that regulates their interaction with receptor and effector molecules. The interaction involves two distinct interfaces and dramatically alters the conformation of the alpha but not of the beta gamma subunits. The location of the known sites for post-translational modification and receptor coupling suggest a plausible orientation with respect to the membrane surface and an activated heptahelical receptor.

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PMID:
8552184
DOI:
10.1038/379311a0
[Indexed for MEDLINE]
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